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交醫生命科學中心 (交一生物材料與再生醫學技術中心)

交一生物材料與再生醫學技術中心專注于自體細胞與生物墨水在再生醫學領域的研究與應用。作為一種前沿的醫學技術，自體細胞能夠通過重新編程和分化，實現人體組織的再生與修復。而生物墨水則是一種含有活體細胞和生物材料的可注入液體，用于3D打印人體組織和器官。

中心的研究團隊致力于開發先進的自體細胞分離、培養和擴增技術，以提高自體細胞在再生醫學中的應用效果。同時，中心還研究設計創新的生物墨水，以解決人工器官和組織移植中的供給問題。

中心與多家醫療機構、科研院所和企業展開合作，共同推動相關技術的發展和轉化。通過深入了解人體生物學特性和創新技術的應用，中心為實現個性化醫療和器官再生提供了有力的支持。

中心的目標是在自體細胞和生物墨水研究方面取得突破性的進展，并將其應用于各種再生醫學領域，包括組織工程、器官再生和藥物篩選。通過跨學科的合作和持續創新，中心致力于為人類健康和醫學進步做出貢獻。

劉昌勝 1967年6月出生于湖北大冶，生物材料學家，中國科學院院士，華東理工大學教授、博士生導師，上海大學校長、黨委副書記 。 長期從事生物材料的研究，發展了多種活性骨修復材料以及生長因子制備和材料活化新技術；研制出自固化磷酸鈣人工骨并獲此類產品注冊證，實現臨床廣泛應用。 劉昌勝提出了仿生人體創傷自愈合過程、構建材料在體內引導組織原位再生的學術思路，利用材料在體內所激發的系列生物學效應， 實現無生命材料向有生命組織的轉化。研制出自固化磷酸鈣人工骨，實現了準確塑形、生物降解、同步成骨特性統一，獲國家藥監局該類產品首張注冊證， 已廣泛應用于臨床。發明了制備人骨生長因子和材料活性化的新方法，研制出活性骨修復體已應用于臨床，取得了滿意的治療效果 。 

學術論著 截至2017年11月，劉昌勝出版著作（教材）4部，發表SCI論文201篇，包括在生物材料領域權威期刊Biomaterials（生物材料）上發表21篇，以及在Chemical Reviews（化學評論）等學術雜志上發表的多篇論文。

Jinyang Li, Xue Qu, Gregory F. Payne, Cheng Zhang, Yuxin Zhang, Jianbo Li, Jie Ren, Hua Hong, Changsheng Liu, Biospecific Self-Assembly of a Nanoparticle Coating for Targeted and Stimuli-Responsive Drug Delivery, Adv. Funct. Mater. 2015. Lingyan Cao, Jing Wang, Juan Hou, Wanli Xing, Changsheng Liu, Vascularization and bone regeneration in a critical sized defect using 2-N,6-O-sulfated chitosan nanoparticles incorporating BMP-2, Biomaterials, 2014, 35(2):684-698. Lingyan Cao, Jerome A. Werkmeister, Jing Wang, Veronica Glattauer, Keith M. McLean*, Changsheng Liu*, Bone regeneration using photocrosslinked hydrogel incorporating rhBMP-2 loaded 2-N, 6-O-sulfated chitosan nanoparticles, Biomaterials, 2014,35(9): 2730-2742. Fan Yang, Jing Wang, Juan Hou, Han Guo, Changsheng Liu, Bone regeneration using cell-mediated responsive degradable PEG-based scaffolds incorporating with rhBMP-2, Biomaterials, 2013, 34: 1514-1528. Jing Zhang, Huanjun Zhou, Kai Yang, Yuan Yuan*, Changsheng Liu*, RhBMP-2-loaded calcium silicate/calcium phosphate cement scaffold with hierarchically porous structure for enhanced bone tissue regeneration, Biomaterials, 2013, 34: 9381-9392. Jun Zhao, Gang Shen, Changsheng Liu, Shaoyi Wang, Wenjie Zhang, Xiaochen Zhang, Xiuli Zhang, Dongxia Ye, Jie Wei, Zhiyuan Zhang, Xinquan Jiang, Enhanced Healing of Rat Calvarial Defects with Sulfated Chitosan-Coated Calcium-Deficient Hydroxyapatite/Bone Morphogenetic Protein 2 Scaffolds, Tissue Engineering Part A, 2012, 18(1-2): 185-197. Deliang Zeng, Lunguo Xia, Wenjie Zhang, Hui Huang, Bin Wei, Qingfeng Huang, Jie Wei, Changsheng Liu, Xinquan Jiang, Maxillary Sinus Floor Elevation Using a Tissue-Engineered Bone with Calcium-Magnesium Phosphate Cement and Bone Marrow Stromal Cells in Rabbits, Tissue Engineering Part A, 2012, 18(7-8): 870-882. Derong Zou, Lian Guo, Jiayu Lu, Xiuli Zhang, Jie Wei, Changsheng Liu, Zhiyuan Zhang, Xinquan Jiang, Engineering of Bone Using Porous Calcium Phosphate Cement and Bone Marrow Stromal Cells for Maxillary Sinus Augmentation with Simultaneous Implant Placement in Goats, Tissue Engineering Part A, 2012, 18(13-14): 1464-1478. Chenglong Dai, Han Guo, Jingxiong Lu, Jianlin Shi, Jie Wei, Changsheng Liu*, Osteogenic evaluation of calcium/magnesium-doped mesoporous silica scaffold with incorporation of rhBMP-2 by synchrotron radiation-based mCT, Biomaterials, 2011, 32: 8506-8517. Wenjie Dong , Yongsheng Li*, Dechao Niu , Zhi Ma , Jinlou Gu , Yi Chen , Wenru Zhao ,Xiaohang Liu , Changsheng Liu , and Jianlin Shi*, Facile Synthesis of Monodisperse Superparamagnetic Fe3O4 Core@hybrid@Au Shell Nanocomposite for Bimodal Imaging and Photothermal Therapy, Adv. Mater. 2011, 23, 5392–5397. Qi Gan, Xunyu Lu, Yuan Yuan, Jiangchao Qian, Huanjun Zhou, Xun Lu, Jianlin Shi, Changsheng Liu*, A magnetic, reversible pH-responsive nanogated ensemble based on Fe3O4 nanoparticles-capped mesoporous silica, Biomaterials, 2011, 32: 1932-1942. Yuan Yuan, Changsheng Liu*, Jiangchao Qian, Jing Wang, Yuan Zhang, Size-mediated cytotoxicity and apoptosis of hydroxyapatite nanoparticles in human hepatoma HepG2 cells, Biomaterials, 2010, 31:730-740. Jie Wei, Junfeng Jia, FanWu, Shicheng Wei, Huanjun Zhou, Hongbo Zhang, Jung-Woog Shin, Changsheng Liu*, Hierarchically microporous/macroporous scaffold of magnesium–calcium phosphate for bone tissue regeneration, Biomaterials, 2010, 31:1260-1269. Chenglong Dai, Changsheng Liu*, Jie Wei, Hua Hong, Qinghui Zhao, Molecular imprinted macroporous chitosan coated mesoporous silica xerogels for hemorrhage control, Biomaterials, 2010, 31:7620-7630. Yan Sheng, Changsheng Liu*, Yuan Yuan, Xinyi Tao, Fan Yang, Xiaoqian Shan, Huanjun Zhou, Feng Xu，Long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and water-soluble chitosan. Biomaterials, 2009, 30: 2340-2348. Jie Wei, Fangping Chen, Jung-Woog Shin, Hua Hong, Chenglong Dai, Jiancan Su, Changsheng Liu*, Preparation and characterization of bioactive mesoporous wollastonite – Polycaprolactone composite scaffold. Biomaterials, 2009,30:1080-1088. Huanjun Zhou, Jiangchao Qian, Jing Wang, Wantong Yao, Changsheng Liu*, Jianguo Chen, Xuehua Cao，Enhanced bioactivity of bone morphogenetic protein-2 with low dose of 2-N,6-O-sulfated chitosan in vitro and in vivo，Biomaterials，2009,30:1715-1724. Chenglong Dai, Yuan Yuan, Changsheng Liu*, Jie Wei, Hua Hong, Xiaosheng Li, Xiaohua Pan, Degradable, antibacterial silver exchanged mesoporous silica spheres for hemorrhage control, Biomaterials, 2009, 30: 5364-5375. Min Yin, Yuan Yuan, Changsheng Liu*, Jing Wang, Development of mussel adhesive polypeptide mimics coating for in-situ inducing re-endothelialization of intravascular stent devices, Biomaterials, 2009, 30 :2764-2773. Jing Wang, Changsheng Liu*, Xin Lu, Min Yin, Copolypeptides of 3,4-Dihydroxypheny- lalanine and L-lysline to Mimic Marine Adhesive Protein, Biomaterials, 2007, 28:3456-3468. Jian Zhao, Changsheng Liu*, Yuan Yuan, Xinyi Tao, Xiaoqian Shan, Yan Sheng, Fan Wu, Preparation of hemoglobin-loaded nano-sized particles with porous structure as oxygen carriers, Biomaterials, 2007, 28:1414-1422. Changsheng Liu*, Huifang Shao, Feiyue Chen, Haiyan Zheng, Rheological Properties of Concentrated Aqueous Injectable Calcium Phosphate Cement Slurry, Biomaterials, 2006, 27: 5003-5013. Changsheng Liu*, Huifang Shao, Feiyue Chen, Haiyan Zheng, Effects of the Granularity of Raw Materials on the Hydration and Hardening Process of Calcium Phosphate Cement, Biomaterials, 2003,24: 4103-4113. Changsheng Liu*, Wei Gai, Songhua Pan, Zisheng Liu, The Exothermal Behavior in the Hydration Process of Calcium Phosphate Cement, Biomaterials, 2003, 24:2995- 3003. Changsheng Liu*, Yue Huang, Jinhua Cui, Kinetics of Hydroxyapatite Precipitation at pH 10 to 11, Biomaterial, 2001, 22:301-306. Jing Wang, Changsheng Liu*, Yufei Liu, Shuo Zhang, Double-Network Interpenetrating Bone Cement via in situ Hybridization Protocol, Advanced Functional Materials, 2010, 20: 3997-4011.

承擔項目 截至2017年11月，劉昌勝作為項目負責人，先后承擔國家重大科學研究計劃項目、國家自然科學基金重點及面上項目、“863”項目、教育部高等學校學科創新引智計劃和教育部創新團隊項目等，國家重大科學研究計劃項目首席科學家。 科研成果獎勵 截至2017年11月，劉昌勝先后獲得國家自然科學獎二等獎（2014年度）、國家科技進步二等獎（2003年度）等多項科技獎勵。獲授權發明專利38項（其中美國授權專利4項）。